Urinary Eosinophils. Arch Intern Med. Coronavirus Resource Center. Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue. Twitter Facebook. This Issue. November James M. Serum creatinine level is increased, from 0. No casts or crystals are seen.
AKI occurs in more than 1 in 5 hospitalizations and is associated with a more than 4-fold increased likelihood of in-hospital mortality at 21 days.
As the signs and symptoms of AIN are nonspecific, and the gold-standard test is renal biopsy, diagnosticians have sought a noninvasive test, such as UEs. In , Galpin et al. In , Linton et al. In , Nolan et al. With Hansel stain, UEs are readily identified by their brilliant red-pink granules.
While initial studies indicated UEs might be diagnostically helpful, subsequent studies did not. In , Corwin et al. These findings showed that UEs were produced by other renal or urinary tract abnormalities, such as urinary tract infections, acute tubular necrosis, and glomerulonephritis. In a second study, Corwin et al.
Sensitivity was improved at the expense of specificity, as Hansel stain was positive in other diagnoses as well. The AIN diagnosis was not confirmed by kidney biopsy in the large majority of patients in this study. Lack of confirmation by biopsy, the gold-standard diagnostic test, was a methodologic flaw of this study and others. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation.
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