Combined serum lidocaine and MEGX levels were significantly higher in group A patients up to 90 minutes peak average of 0. Conclusions: Data from this study demonstrate that topical anesthetic for facial rejuvenation can be enhanced with laser pretreatment while maintaining safe blood serum levels.
Further studies should examine optimal application amount and time to allow safe multipass facial rejuvenation without the need for invasive nerve blocks. Keywords: cosmetic medicine; laser-assisted transdermal delivery; pain; research; topical anesthetics.
Abstract Background: Injectable forms of anesthesia for nonsurgical facial rejuvenation, although efficacious, are uncomfortable for the patient.
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This content does not have an Arabic version. See more conditions. Several lidocaine-containing topical anesthetics are available for purchase over the counter OTC. Recently, the authors' group has shown that there is great interindividual discrepancy in the manner in which lidocaine is absorbed and metabolized for even a single OTC product.
Objectives: The authors compare five commonly-available lidocaine preparations and their levels of absorption when applied to the face. Three of the preparations are available OTC; two require prescriptions and were compounded in a pharmacy.
Methods: Twenty-five subjects enrolled in this Institutional Review Board-approved study were randomly assigned to one of five groups.
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